Rodent Systems (Plasmodium berghei-Anopheles stephensi) for Screening Compounds for Potential Causal Prophylaxis

Harry Most; Winifred A. Montuori

doi:10.4269/ajtmh.1975.24.179

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Rodent Systems (Plasmodium berghei-Anopheles stephensi) for Screening Compounds for Potential Causal Prophylaxis

Harry Most

Harry Most Department of Preventive Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016

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Winifred A. Montuori

Winifred A. Montuori Department of Preventive Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016

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DOI:: https://doi.org/10.4269/ajtmh.1975.24.179

Volume/Issue:: Volume 24: Issue 2

Page(s):: 179–182

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An in vivo screening system is described in which drugs administered to rats or mice and challenged with sporozoites are evaluated for their antimalarial properties (causal prophylaxis, suppression, therapy) by the presence or absence of exoerythrocytic forms and parasitemia. The system is composed of A/J mice, Sprague-Dawley rats, Plasmodium berghei, and Anopheles stephensi. Good correlation has been found between test results and practical application.

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Copyright:: Copyright © 1975 by The American Society of Tropical Medicine and Hygiene 1975

Accepted:: 01 Nov 1974
Published Online:: Mar 1975

The American Journal of Tropical Medicine and Hygiene

Print ISSN:: 0002-9637

A Field Experiment in Quinine Treatment

Author:

Ralph K. Collins

Biographisches Lexicon der hervorragenden Arzte de letzten funfzig Jahre

By I. Fischer. Privaudozent an der Universitat Wien. In II parts. Illustrated. Urban & Schwarzebberg, Berlin and Wien.

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Authors:

D. H. Cook

and

J. H. Axtmayer

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By Prof. R. Newstead, F.R.S., with the collaboration of Alwen W. Evans, M.Sc. (Vict.) and W. H. Potts, B.A. (Contab.). Foreword by Prof. J. W. W. Stevens, F.R.S. Liverpool School of Tropical Medicine—Memoir, New Series No. 1. The University Press of Liverpool Limited. Hodder and Stoughten Limited, London. Price 17/6 net

Author:

J. H. St. John

A Fifth Year's Observations on Malaria in Panama, with Reference to the Failure of Atabrine to Control an Epidemic

Authors:

W. H. W. Komp

and

H. C. Clark

	Past two years	Past Year	Past 30 Days
Abstract Views	875	548	97
Full Text Views	4	0	0
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