Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
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0002-9637
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Biological Screening in the U. S. Army Antimalarial Drug Development Program

Kenneth E. KinnamonDivision of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012

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William E. RotheDivision of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012

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DOI:
https://doi.org/10.4269/ajtmh.1975.24.174
Volume/Issue:
Volume 24: Issue 2
Page(s):
174–178
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The methods of testing drugs in the United States Army Antimalarial Drug Development Program are described. To date over two hundred thousand compounds have been screened. For each 3,000 compounds evaluated in the primary screen, only 1 is assessed for efficacy in the final test system. Of those potential antimalarials assessed in this last system, only about half are deemed worthy of preclinical toxicological evaluation.
Copyright:
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene 1975
Accepted:
03 Aug 1974
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Published Online:
Mar 1975
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