Biological Screening in the U. S. Army Antimalarial Drug Development Program

Kenneth E. Kinnamon Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012

Search for other papers by Kenneth E. Kinnamon in
Current site
Google Scholar
PubMed
Close
and
William E. Rothe Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012

Search for other papers by William E. Rothe in
Current site
Google Scholar
PubMed
Close
Restricted access

The methods of testing drugs in the United States Army Antimalarial Drug Development Program are described. To date over two hundred thousand compounds have been screened. For each 3,000 compounds evaluated in the primary screen, only 1 is assessed for efficacy in the final test system. Of those potential antimalarials assessed in this last system, only about half are deemed worthy of preclinical toxicological evaluation.

Author Notes

Past two years Past Year Past 30 Days
Abstract Views 1124 793 87
Full Text Views 9 1 0
PDF Downloads 8 1 0
 

 

 

 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save