Experimental Infection of the Cotton Mouse (Peromyscus Gossypinus) with Venezuelan Equine Encephalomyelitis Virus

William J. BiglerVeterinary Public Health Section and Epidemiology Research Center, Division of Health, Department of Health and Rehabilitative Services, Jacksonville, Florida 32201

Search for other papers by William J. Bigler in
Current site
Google Scholar
PubMed
Close
,
Arthur L. LewisVeterinary Public Health Section and Epidemiology Research Center, Division of Health, Department of Health and Rehabilitative Services, Jacksonville, Florida 32201

Search for other papers by Arthur L. Lewis in
Current site
Google Scholar
PubMed
Close
, and
Flora M. WellingsVeterinary Public Health Section and Epidemiology Research Center, Division of Health, Department of Health and Rehabilitative Services, Jacksonville, Florida 32201

Search for other papers by Flora M. Wellings in
Current site
Google Scholar
PubMed
Close
Restricted access

Eighteen cotton mice (Peromyscus gossypinus) were divided into four groups: seropositive and seronegative adults, and subadults with and without a history of maternal antibody. After intraperitoneal inoculation of 0.5 ml of Fe3-7C virus suspension containing 800 MLD50, virus was recovered from the blood of 2 of 4 nonimmun adults and from both groups of subadults. Viremias persisted up to 4 days in some individuals with mean titers ranging from 7.4 log10 MLD50 per ml on day 1 to 3.9 log10 MLD50 per ml on day 4. Virus was not recovered from the group of seropositive adults, 2 of 4 seronegative adults, or the uninoculated seronegative contact animals of each group. Hemagglutination-inhibiting antibodies were detected in all mice 8 days post-inoculation, with titers ranging from 1:20 to 1:320 by day 35.

Save