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Experimental Infection of the Cotton Mouse (Peromyscus Gossypinus) with Venezuelan Equine Encephalomyelitis Virus
William J. Bigler
William J. Bigler
Veterinary Public Health Section and Epidemiology Research Center, Division of Health, Department of Health and Rehabilitative Services, Jacksonville, Florida 32201
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Arthur L. Lewis
Arthur L. Lewis
Veterinary Public Health Section and Epidemiology Research Center, Division of Health, Department of Health and Rehabilitative Services, Jacksonville, Florida 32201
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Flora M. Wellings
Flora M. Wellings
Veterinary Public Health Section and Epidemiology Research Center, Division of Health, Department of Health and Rehabilitative Services, Jacksonville, Florida 32201
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Eighteen cotton mice (Peromyscus gossypinus) were divided into four groups: seropositive and seronegative adults, and subadults with and without a history of maternal antibody. After intraperitoneal inoculation of 0.5 ml of Fe3-7C virus suspension containing 800 MLD50, virus was recovered from the blood of 2 of 4 nonimmun adults and from both groups of subadults. Viremias persisted up to 4 days in some individuals with mean titers ranging from 7.4 log10 MLD50 per ml on day 1 to 3.9 log10 MLD50 per ml on day 4. Virus was not recovered from the group of seropositive adults, 2 of 4 seronegative adults, or the uninoculated seronegative contact animals of each group. Hemagglutination-inhibiting antibodies were detected in all mice 8 days post-inoculation, with titers ranging from 1:20 to 1:320 by day 35.
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