Heat Treatment of Mycobacterium Ulcerans Infections without Surgical Excision

Wayne M. Meyers Leprosy Atelier, Department of Pathology, University of Hawaii School of Medicine, Department of Surgery, Institut Médical Evangélique, Kimpese via Kinshasa, Republic of Zaire, and Geographic Pathology Division, Armed Fores Institute of Pathology, Honolulu, Hawaii 96816

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Walter M. Shelly Leprosy Atelier, Department of Pathology, University of Hawaii School of Medicine, Department of Surgery, Institut Médical Evangélique, Kimpese via Kinshasa, Republic of Zaire, and Geographic Pathology Division, Armed Fores Institute of Pathology, Honolulu, Hawaii 96816

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Daniel H. Connor Leprosy Atelier, Department of Pathology, University of Hawaii School of Medicine, Department of Surgery, Institut Médical Evangélique, Kimpese via Kinshasa, Republic of Zaire, and Geographic Pathology Division, Armed Fores Institute of Pathology, Honolulu, Hawaii 96816

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DOI:
https://doi.org/10.4269/ajtmh.1974.23.924
Volume/Issue:
Volume 23: Issue 5
Page(s):
924–929
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Eight patients from Zaire with Mycobacterium ulcerans infections were treated by the local application of heat to maintain a temperature of approximately 40°C in the ulcerated area. All lesions healed without surgical intervention and without local recurrences during follow-up periods of up to 22 months. This study shows that local heat promotes healing of M. ulcerans lesions. We postulate that the mechanism is primarily by direct inhibition of multiplication of M. ulcerans. Other possible contributory effects are discussed.

Author Notes

Copyright:
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene 1974
Accepted:
08 Mar 1974
|
Published Online:
Sep 1974
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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