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Inhibition of the Immune Response to Pertussis Vaccine during Plasmodium Berghei Yoelii Infection in Mice

Pierre ViensDepartment of Microbiology and Immunology, University of Montreal, Institute of Microbiology and Hygiene of Montreal, Laval-des-Rapides, Montreal, Canada

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Abdellaziz TarzaaliDepartment of Microbiology and Immunology, University of Montreal, Institute of Microbiology and Hygiene of Montreal, Laval-des-Rapides, Montreal, Canada

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Marc QuevillonDepartment of Microbiology and Immunology, University of Montreal, Institute of Microbiology and Hygiene of Montreal, Laval-des-Rapides, Montreal, Canada

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Mice infected with Plasmodium berghei yoelii responded poorly to pertussis vaccine when administered at peak parasitemia. This was shown by serum agglutinin titers and lack of protection against intracerebral challenge with virulent Bordetella pertussis.

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