Immunological Reactions in Kuru

Attempts to Demonstrate Serological Relationships between Kuru and other Known Infectious Agents

R. J. BenfanteNational Institte of Neurological Diseases and Stroke, National Institutes of Health, Department of Bacteriology, University of Singapore, Bethesda, Maryland 20014, Singapore

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R. D. TraubNational Institte of Neurological Diseases and Stroke, National Institutes of Health, Department of Bacteriology, University of Singapore, Bethesda, Maryland 20014, Singapore

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K. A. LimNational Institte of Neurological Diseases and Stroke, National Institutes of Health, Department of Bacteriology, University of Singapore, Bethesda, Maryland 20014, Singapore

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J. HooksNational Institte of Neurological Diseases and Stroke, National Institutes of Health, Department of Bacteriology, University of Singapore, Bethesda, Maryland 20014, Singapore

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C. J. Gibbs Jr.National Institte of Neurological Diseases and Stroke, National Institutes of Health, Department of Bacteriology, University of Singapore, Bethesda, Maryland 20014, Singapore

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D. C. GajdusekNational Institte of Neurological Diseases and Stroke, National Institutes of Health, Department of Bacteriology, University of Singapore, Bethesda, Maryland 20014, Singapore

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A total of 201 kuru patients and 49 chimpanzees affected with experimental kuru have been screened for antibody against 65 infectious agents in the search for high antibody titers and high frequencies of positive reactions with the purpose of discovering an antigen which might be serologically related to the virus of kuru. None of the agents studied gave an antibody response or pattern of positive reactivity that was significantly different from those encountered in surrounding kuru-free populations or in normal chimpanzees. This suggests that none of the infectious agents studied has an association with the pathology of kuru.

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