Urine Tests to Monitor the Self-Administration of Dapsone by Leprosy Patients

G. A. EllardMedical Research Council's Unit for Laboratory Studies of Tuberculosis, Royal Postgraduate Medical School, Leprosy Research Unit, National Leprosy Control Centre, Laboratory for Leprosy and Mycobacterial Research, National Institute for Medical Research, London W12 OHS

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Patricia T. GammonMedical Research Council's Unit for Laboratory Studies of Tuberculosis, Royal Postgraduate Medical School, Leprosy Research Unit, National Leprosy Control Centre, Laboratory for Leprosy and Mycobacterial Research, National Institute for Medical Research, London W12 OHS

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H. S. HelmyMedical Research Council's Unit for Laboratory Studies of Tuberculosis, Royal Postgraduate Medical School, Leprosy Research Unit, National Leprosy Control Centre, Laboratory for Leprosy and Mycobacterial Research, National Institute for Medical Research, London W12 OHS

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R. J. W. ReesMedical Research Council's Unit for Laboratory Studies of Tuberculosis, Royal Postgraduate Medical School, Leprosy Research Unit, National Leprosy Control Centre, Laboratory for Leprosy and Mycobacterial Research, National Institute for Medical Research, London W12 OHS

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Three qualitative and one simple quantitative urine test methods are described for monitoring the self-administration of daily doses of dapsone (DDS) by leprosy patients. The qualitative methods can be employed for monitoring the taking of daily doses of 50 mg DDS or more. In the quantitative method the ratio of DDS plus its diazotizable metabolites to creatinine in the urine is determined using simple colorimetric methods. This method is considerably more sensitive and efficient than the qualitative methods and is capable of monitoring the taking of daily doses of DDS of as little as 10 mg.

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