Schistosomiasis Japonica in the Philippines: Results of Standardized Immediate Intradermal (ID) Tests

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  • Department of Microbiology, University of Chicago, Chicago, Illinois 60637

With standardized technics and a Coca's extract of Schistosoma japonicum worms (Philippine-Leyte strain) at 27 to 30 µg N/ml as antigen, the intradermal test (immediate reaction) for schistosomiasis japonica in the Philippines showed an overall sensitivity of 88.2% among known infected individuals and a non-specificity of 3% among uninfected Filipinos. Sensitivity was 95% or better in those 12 years or older, but significantly less (65%) in younger individuals. A false-positive rate of up to 9% was found among American Peace Corps volunteers in the Philippines; a false-positive response of 37.5% was found in Filipinos infected with Capillaria philippinensis. Antigens prepared from S. mansoni and Schistosomatium douthitti worms were significantly less sensitive in detecting schistosomiasis japonica; however, an antigen prepared from the Japanese strain of S. japonicum had a comparable sensitivity to the antigen prepared from the Philippine-Leyte strain.