An American Foreign Service family of three was found to have Schistosoma intercalatum infection upon their return from residence in Kisangani, Zaire. Only one case was possibly symptomatic, infections appeared to be light, and all were apparently cured with a course of niridazole. Outside of the two recognized foci of S. intercalatum in Africa, infection has been described in Europe almost exclusively in immigrant Africans from these foci. The present three cases are the first reported in this country. Clinical, biological, and epidemiological evidence is cited for regarding S. intercalatum as a distinct species and the disease produced by it is reviewed.