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Comparative Susceptibility of Eight Mosquito Species to Sindbis Virus
Bernard A. Schiefer
Bernard A. Schiefer
Department of Entomology, Walter Reed Army Institute of Research, Washington, D. C. 20012
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James R. Smith
James R. Smith
Department of Entomology, Walter Reed Army Institute of Research, Washington, D. C. 20012
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An evaluation of the susceptibility of eight mosquito species to Sindbis virus was conducted as a prelude to studies on the mechanisms of arbovirus infection in mosquitoes at the cellular and molecular level. Culex tritaeniorhynchus was the most susceptible mosquito tested, with an ID10 of 2.42 log10 TCID50. Considerably higher infectivity thresholds were observed with C. salinarius (4.41) and Aedes aegypti (4.46), but these species did show persistence of virus which may indicate multiplication. Anopheles quadrimaculatus, An. stephensi, Aedes taeniorhynchus and Ae. triseriatus became infected only at high doses and all showed reduced virus titers after 7 days post-infection. Armigeres subalbatus were refractory to infection at all doses tested.
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