Response to Treatment in Man of Multidrug Resistant Plasmodium Falciparum from Panama

Richard H. GlewSection on Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Parasitic Diseases, National Institutes of Health, U.S. Penitentiary, Atlanta, Georgia 30315

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Louis H. MillerSection on Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Parasitic Diseases, National Institutes of Health, U.S. Penitentiary, Atlanta, Georgia 30315

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William E. CollinsSection on Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Parasitic Diseases, National Institutes of Health, U.S. Penitentiary, Atlanta, Georgia 30315

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Willam A. HowardSection on Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Parasitic Diseases, National Institutes of Health, U.S. Penitentiary, Atlanta, Georgia 30315

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David J. WylerSection on Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Parasitic Diseases, National Institutes of Health, U.S. Penitentiary, Atlanta, Georgia 30315

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Enrique Chaves-CarballoSection on Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Parasitic Diseases, National Institutes of Health, U.S. Penitentiary, Atlanta, Georgia 30315

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Franklin A. NevaSection on Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Parasitic Diseases, National Institutes of Health, U.S. Penitentiary, Atlanta, Georgia 30315

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A strain of Plasmodium falciparum isolated in the Republic of Panama in March 1972 was transferred to the Unit on Human Malaria (LPD, NIAID, NIH) in Atlanta, Georgia. Studies in eight non-immune prisoner volunteers demonstrated that infections with this Panama II strain of P. falciparum recrudesced following treatment with chloroquine 1.5 g (base), amodiaquine 1.4 g (base), chlorguanide 1.3 g (base) over 5 days, or quinine 11.34 g (base) over 7 days. Parasitemia increased during therapy with pyrimethamine 150 mg over 3 days. Infections were cured by treatment with quinine for 10 days (16.2 g base) or by combination therapy with sulfadiazine (10 g in 5 days) plus pyrimethamine (150 mg in 3 days).

Author Notes

Present address: Mayo Clinic, Rochester, Minnesota 55901.

Present address: Mayo Graduate School of Medicine, Rochester, Minnesota 55901, formerly of Gorgas Hospital, Ancon, Canal Zone.

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