Further observations on the primary paranasal aspergillus granuloma in the Sudan: A morphological study of 46 cases

Béla Veress Department of Pathology, Faculty of Medicine, University of Khartoum, Democratic Republic of the Sudan

Search for other papers by Béla Veress in
Current site
Google Scholar
PubMed Close
,
Osman A. Malik Department of Pathology, Faculty of Medicine, University of Khartoum, Democratic Republic of the Sudan

Search for other papers by Osman A. Malik in
Current site
Google Scholar
PubMed Close
,
Ahmed A. El Tayeb Department of Pathology, Faculty of Medicine, University of Khartoum, Democratic Republic of the Sudan

Search for other papers by Ahmed A. El Tayeb in
Current site
Google Scholar
PubMed Close
,
Sayed El Daoud Department of Pathology, Faculty of Medicine, University of Khartoum, Democratic Republic of the Sudan

Search for other papers by Sayed El Daoud in
Current site
Google Scholar
PubMed Close
,
El S. Mahgoub Department of Pathology, Faculty of Medicine, University of Khartoum, Democratic Republic of the Sudan

Search for other papers by El S. Mahgoub in
Current site
Google Scholar
PubMed Close
, and
Ahmed M. El Hassan Department of Pathology, Faculty of Medicine, University of Khartoum, Democratic Republic of the Sudan

Search for other papers by Ahmed M. El Hassan in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1973.22.765
Volume/Issue:
Volume 22: Issue 6
Page(s):
765–772
Restricted access
Get Permissions

The morphological changes in 46 cases of primary paranasal aspergillus granuloma seen in the Sudan are described. Histologically, three groups can be differentiated: 1) a proliferative type, characterized by the presence of pseudotubercles in a fibrous tissue stroma; 2) an exudative-necrotizing type, consisting of large foci of edematous necrosis; and 3) a mixed group, where proliferation and necrosis exist side by side. Fungal hyphae are seen both within the giant cells and lying free in the stroma. Three factors seem to play a part in the pathogenesis of this disease: a) the climatic conditions, inducing recurrent inflammation of the nasal sinuses; b) the ability of the fungus and its toxic metabolites to cause damage; and c) an immunological process produced by the fungal antigens. The latter is supported by the finding of fibrinoid necrosis of collagen, vascular alterations, and formation of pseudotubercles.

Copyright:
© 1973 by The American Journal of Tropical Medicine and Hygiene 1973
Accepted:
19 May 1973
|
Published Online:
Nov 1973
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 391 186 5
Full Text Views 11 1 0
PDF Downloads 6 1 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save