Complement profile in leprosy

Bencha Petchclai Clinical Immunology Laboratory, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand, and Rajaprachasamasai Institute, Department of Health, Phrapradang, Samutprakarn, Thailand

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Rochana Chutanondh Clinical Immunology Laboratory, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand, and Rajaprachasamasai Institute, Department of Health, Phrapradang, Samutprakarn, Thailand

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Sopaporn Prasongsom Clinical Immunology Laboratory, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand, and Rajaprachasamasai Institute, Department of Health, Phrapradang, Samutprakarn, Thailand

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Supaporn Hiranras Clinical Immunology Laboratory, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand, and Rajaprachasamasai Institute, Department of Health, Phrapradang, Samutprakarn, Thailand

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Teera Ramasoota Clinical Immunology Laboratory, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand, and Rajaprachasamasai Institute, Department of Health, Phrapradang, Samutprakarn, Thailand

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DOI:
https://doi.org/10.4269/ajtmh.1973.22.761
Volume/Issue:
Volume 22: Issue 6
Page(s):
761–764
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We investigated complement in leprosy to detect its possible role in pathogenesis. Complement components, C3 proactivator (C3PA), CH50 and anticomplementary activity (AC) were determined in sera collected from lepromatous and tuberculoid leprosy. C3 was found increased in lepromatous leprosy and highly increased C3PA was found in both groups. Changes in other components lacked specific pattern. Increases in C3PA levels are believed to be due to aggregation of the increased serum immunoglobulins. C3 levels and CH50 levels in the present study agree with those in other reports. Development of AC occurred in lepromatous sera even during 2 days of storage at –80° C. AC found among freshly collected sera was probably due to aggregated immunoglobulins. The present study serves as a groundwork for future investigations.

Copyright:
© 1973 by The American Journal of Tropical Medicine and Hygiene 1973
Accepted:
07 Apr 1973
|
Published Online:
Nov 1973
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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