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Schistosoma mansoni: Chemoprophylaxis studies with antipenetration compounds
Frederick G. Austin
Frederick G. Austin
Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014
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Philip J. Frappaolo
Philip J. Frappaolo
Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014
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Five topical ointments, each with the potential of preventing percutaneous infection by human schistosome cercariae, were tested over an 8-day period on mouse tails exposed to Schistosoma mansoni cercariae. In terms of worm burden reduction compared to controls, ointment CL-28A without carboset resins significantly reduced infection between 61% and 34% for 5 days; ointment CL-28 with carboset resins, between 73% and 23% for at least 6 days; ointment 25% Pterodon pubescens oil extract in ether, between 100% (first 3 days post treatment) and 43% for 6 days; ointment 1 part P. pubescens in 4 parts CL-28A, between 100% (first 2 days post treatment) and 42% for 5 days; and ointment 1 part lapachol in 100 parts CL-28A, between 100% and 33% for 8 days.
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