Plasmodium cynomolgi malaria: Accidental human infection

Harry Most Department of Preventive Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016

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A student repeatedly in contact with monkeys and mosquitoes infected with Plasmodium cynomolgi developed chills and a tertian pattern of fever which proved to be malaria. Parasitemia was submicroscopic, except on one occasion. However, the patient's blood on the 7th day of his illness was injected into a monkey, resulting in infection 7 days later. Clinically, the mild illness was characterized by severe headache, no abnormal objective physical signs, and slight though significant alterations in some hematologic and biochemical parameters.

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