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Hemoglobin A2 and malaria
G. J. Folayan Esan
G. J. Folayan Esan
Department of Haematology, University College Hospital, Ibadan, and Sacred Heart Hospital, Abeokuta, Nigeria
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Ulrich Bienzle
Ulrich Bienzle
Department of Haematology, University College Hospital, Ibadan, and Sacred Heart Hospital, Abeokuta, Nigeria
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Gotthold Hiller
Gotthold Hiller
Department of Haematology, University College Hospital, Ibadan, and Sacred Heart Hospital, Abeokuta, Nigeria
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T. A. O. Adesina
T. A. O. Adesina
Department of Haematology, University College Hospital, Ibadan, and Sacred Heart Hospital, Abeokuta, Nigeria
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The concentration of hemoglobin A2 in red cell hemolysates from 81 children with Plasmodium falciparum malaria has been compared with that of 30 children without malaria living in the same environment. The result in subjects with malaria—2.39% ± 0.055 (mean ± se)—was not significantly different from the value of 2.30% ± 0.12 in those without malaria (P > 0.2). No difference was found in the levels during and 2 months after an attack of malaria. It is concluded that, in the population studied, malaria does not affect the usefulness of a raised concentration of hemoglobin A2 in the diagnosis of beta thalassemia minor.
Author Notes
Dr. Bienzle is a Fellow of the Deutsche Forschungsgemeinschaft.
Dr. Hiller is on secondment to the Sacred Heart Hospital from the Institute of Tropical Medicine, University of Tubingen, West Germany.
| Past two years | Past Year | Past 30 Days | |
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