IgM antibodies to red cells and autoimmune anemia in patients with malaria

Eugene B. Rosenberg Department of Clinical Investigation, U. S. Naval Medical Research Unit No.2, Taipei, Taiwan

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G. Thomas Strickland Department of Clinical Investigation, U. S. Naval Medical Research Unit No.2, Taipei, Taiwan

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Sen-Lian Yang Department of Clinical Investigation, U. S. Naval Medical Research Unit No.2, Taipei, Taiwan

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George E. Whalen Department of Clinical Investigation, U. S. Naval Medical Research Unit No.2, Taipei, Taiwan

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DOI:
https://doi.org/10.4269/ajtmh.1973.22.146
Volume/Issue:
Volume 22: Issue 2
Page(s):
146–152
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Rising titers of IgM antibodies to red blood cells were found in 56 patients following infection with Plasmodium falciparum parasites. These antibodies, detected by indirect immunofluorescence using fluorescein-conjugated monospecific antisera, were not present in the sera of 23 non-malaria patients with high IgM concentration, 9 patients with infectious, malignant, and autoimmune diseases, and 16 normal subjects. Rising titers of IgM erythrocyte antibodies were associated with an increase of mean IgM from 100 to 500 mg/100 ml and a decrease of mean C3 from 150 to 75 mg/lOO ml over 24 days. Mean concentrations of serum IgA, IgG, IgD, IgE, albumin, globulin, and total protein were not significantly different in patients and controls throughout the study. IgM erythrocyte antibody titers and serum IgM levels were highest, and serum C3 were lowest in the most anemic patients. Survival time of 51Cr-tagged normal red cells was reduced in 10 of 11 patients studied following the clearance of malarial parasitemia and was the shortest in the most anemic patients.

Author Notes

Present address: Division of Nuclear Medicine, Jackson Memorial Hospital, University of Miami, Miami, Florida 33152.

Present address: U. S. Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014.

Present address: Department of Obstetrics and Gynecology, Unhtersity of Pennsylvania, Philadelphia, Pennsylvania.

Present address: Department of Medicine, Columbia Hospital and V.A. Hospital, Medical College of Wisconsin, Milwaukee, Wisconsin.

Address reprint requests to: Publications Office, NAMRU 2, APO San Francisco, California 96263.
Copyright:
© 1973 by The American Journal of Tropical Medicine and Hygiene 1973
Accepted:
23 Sep 1972
|
Published Online:
Mar 1973
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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