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The concentration of serum IgE in four human helminthiases was determined by an indirect single radial immunodiffusion method. Whereas in most normal adults serum levels of IgE were below 300 units/ml, raised levels of IgE were found in patients infected with helminths. Mean values were 1,210 units/ml in 60 cases of schistosomiasis japonica, 3,400 units/ml in 5 cases of paragonimiasis, 2,960 units/ml in 4 cases of fascioliasis hepatica, and 570 units/ml in 10 cases of hookworm infection. The results clearly indicate that an increase of serum IgE concentration occurs in various helminthic infections, although the significance of this is still obscure.
Present address: Department of Pathology, New York University Medical Center, New York, N.Y. 10016.