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Experimental Infections with African Trypanosomes
II. Immunization of Mice and Monkeys with a Gamma-Irradiated, Recently Isolated Human Strain of Trypanosoma rhodesiense
Ralph E. Duxbury
Ralph E. Duxbury
Department of Medical Zoology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012
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Elvio H. Sadun
Elvio H. Sadun
Department of Medical Zoology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012
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J. Scott Anderson
J. Scott Anderson
Department of Medical Zoology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012
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A recently isolated human strain of Trypanosoma rhodesiense (EATRO No. 1886) from Uganda was infective for mice and rhesus monkeys. Mice receiving two or three immunizing inoculations of gamma-irradiated trypanosomes were markedly protected from a challenge infection of 1,000 unirradiated organisms 1 week after immunization. Complete protection from a challenge infection was induced in 5 of 6 monkeys given six immunizing inoculations with irradiated trypanosomes. Conversely, the five unimmunized controls became patent 5 to 8 days after challenge with 10,000 unirradiated organisms, showed signs of progressive severe illness, and died between 12 and 49 days after challenge.
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