Effects of Minocycline against Chloroquine-Resistant Falciparum Malaria

D. Willerson Jr. Walter Reed Army Institute of Research, Army Medical Research Project, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Joliet, Illinois

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K. H. Rieckmann Walter Reed Army Institute of Research, Army Medical Research Project, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Joliet, Illinois

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P. E. Carson Walter Reed Army Institute of Research, Army Medical Research Project, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Joliet, Illinois

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H. Frischer Walter Reed Army Institute of Research, Army Medical Research Project, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Joliet, Illinois

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DOI:
https://doi.org/10.4269/ajtmh.1972.21.857
Volume/Issue:
Volume 21: Issue 6
Page(s):
857–862
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The antimalarial effects of minocycline, a semi-synthetic tetracycline, were evaluated in chloroquine-resistant Plasmodium falciparum infections. Nine volunteers infected with the Vietnam (Marks) strain were cured after each received a 7-day course of minocycline. Two additional subjects infected with the same Vietnamese strain were cured after each received a combination of minocycline and quinine. Minocycline protected 16 of 18 volunteers after challenge with Anopheles stephensi mosquitoes infected with chloroquine-resistant strains of P. falciparum. Eleven men were protected against a single challenge by mosquitoes infected with the Cambodia (Buchanan) strain. Five of seven volunteers were protected against a single challenge by mosquitoes infected with the Vietnam (Marks) strain. No sporontocidal or gametocytocidal effects occurred in one volunteer who received a 7-day course of minocycline.

Author Notes

Present address: 4627 Edmondson, Dallas, Texas 75209.

Copyright:
Copyright © 1972 by The American Society of Tropical Medicine and Hygiene 1972
Accepted:
13 May 1972
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Published Online:
Nov 1972
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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