Effects of Minocycline against Chloroquine-Resistant Falciparum Malaria

View More View Less
  • Walter Reed Army Institute of Research, Army Medical Research Project, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Joliet, Illinois
Restricted access

The antimalarial effects of minocycline, a semi-synthetic tetracycline, were evaluated in chloroquine-resistant Plasmodium falciparum infections. Nine volunteers infected with the Vietnam (Marks) strain were cured after each received a 7-day course of minocycline. Two additional subjects infected with the same Vietnamese strain were cured after each received a combination of minocycline and quinine. Minocycline protected 16 of 18 volunteers after challenge with Anopheles stephensi mosquitoes infected with chloroquine-resistant strains of P. falciparum. Eleven men were protected against a single challenge by mosquitoes infected with the Cambodia (Buchanan) strain. Five of seven volunteers were protected against a single challenge by mosquitoes infected with the Vietnam (Marks) strain. No sporontocidal or gametocytocidal effects occurred in one volunteer who received a 7-day course of minocycline.

Author Notes

Present address: 4627 Edmondson, Dallas, Texas 75209.

Save