Studies on the Characterization of Plasmodium Vivax Strains from Central America

Peter G. ContacosSection on Primate Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Central America Malaria Research Station, Chamblee, Georgia 30341, El Salvador

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William E. CollinsSection on Primate Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Central America Malaria Research Station, Chamblee, Georgia 30341, El Salvador

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Geoffrey M. JefferySection on Primate Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Central America Malaria Research Station, Chamblee, Georgia 30341, El Salvador

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Wojciech A. KrotoskiSection on Primate Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Central America Malaria Research Station, Chamblee, Georgia 30341, El Salvador

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William A. HowardSection on Primate Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Central America Malaria Research Station, Chamblee, Georgia 30341, El Salvador

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Summary

Four strains of vivax malaria from three Central American countries (Panama, El Salvador, Nicaragua) were studied in volunteers for characteristics of their relapse patterns and for their response to recommended dosage regimens of some standard antimalarial drugs. The relapse patterns of the four Central American vivax strains fell into the “temperate zone” category of relapse pattern; namely, an early primary attack (short prepatent period) followed by a long period of latency before appearance of frequent relapse activity. The characteristics and classification of relapse patterns are discussed.

Author Notes

Present address: Malaria Program, Center for Disease Control, Atlanta, Georgia 30333.

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