The Epidemiologic Interpretation of Serologic Data in Malaria

C. C. DraperLondon School of Hygiene and Tropical Medicine, Keppel Street, London W. C. 1

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A. VollerLondon School of Hygiene and Tropical Medicine, Keppel Street, London W. C. 1

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R. G. CarpenterLondon School of Hygiene and Tropical Medicine, Keppel Street, London W. C. 1

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Summary

The indirect fluorescent antibody test promises to be of value for epidemiologic work in malaria. Some of the variables which may affect this test are discussed briefly. A mathematical model for analyzing age-related antibody prevalence rates is described and its application is illustrated by data from recent surveys in East Africa and in Amazonas, Brazil. Fallacies and difficulties, such as congenital antibodies and the use of simian parasites as antigens, are discussed, together with conditions where the use of serologic methods may be valuable.

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