The Relative Chemotherapeutic Efficacy of a Nitrovinylfuran (SQ 18,506) against Immature and Mature Stages of Schistosoma Mansoni

Robert W. LennoxDepartment of Pathobiology, School of Hygiene and Public Health, and Department of Pharmacology and Experimental Therapeutics, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205

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Ernest BuedingDepartment of Pathobiology, School of Hygiene and Public Health, and Department of Pharmacology and Experimental Therapeutics, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205

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The antischistosomal nitrovinylfuran trans-5-amino-3-[2-(5-nitro-2 furyl)-vinyl]-1,2,4 oxadiazole (SQ 18,506) had pronounced chemotherapeutic activity when administered orally to mice at various stages during the development of the parasite, i.e., between 1 and 44 days after infection with cercariae of Schistosoma mansoni. This activity was greater than that observed when identical treatment was initiated at 56 or 125 days post-infection. A single intramuscular injection of SQ 18,506 at 1 or 8 days prior to infection had a marked prophylactic effect. Similar treatment administered 2 or 3 weeks prior to infection did not result in complete protection but produced a significant reduction in worm burdens.

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