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Kinetic Testing of Drugs Against Mycobacterium Leprae in Mice
Activity of Cephaloridine, Rifampin, Streptovaricin, Vadrine, and Viomycin
Charles C. Shepard
Charles C. Shepard
Leprosy and Rickettsial Diseases Unit, Virology Section, Center for Disease Control, Atlanta, Georgia 30333
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Laura L. Walker
Laura L. Walker
Leprosy and Rickettsial Diseases Unit, Virology Section, Center for Disease Control, Atlanta, Georgia 30333
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Rosalind M. Van Landingham
Rosalind M. Van Landingham
Leprosy and Rickettsial Diseases Unit, Virology Section, Center for Disease Control, Atlanta, Georgia 30333
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Martha A. Redus
Martha A. Redus
Leprosy and Rickettsial Diseases Unit, Virology Section, Center for Disease Control, Atlanta, Georgia 30333
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A series of drugs that had been found active against Mycobacterium leprae in mice by the continuous method of drug administration was tested by the kinetic method. Vadrine and viomycin were found inactive. Cephaloridine, streptovaricin, and rifampin gave bactericidal-type results. In a second experiment, rifampin was found to have distinct bactericidal effect when given for only 2 days. The plasma levels of rifampin that were associated with bactericidal effect in mice were in the range reported for man receiving acceptable dosages of rifampin. Cephaloridine and, especially, rifampin merit further investigation in clinical trials in leprosy patients, either as single drugs or in combination with other active drugs. The combination of rifampin and dapsone (DDS) or acedapsone (DADDS) appear to provide the advantages of both drugs.
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| Past two years | Past Year | Past 30 Days | |
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