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Cutaneous Leishmaniasis in the Guinea Pig
Delayed-Type Hypersensitivity, Lymphocyte Stimulation, and Inhibition of Macrophage Migration
T. M. Blewett
T. M. Blewett
Laboratory of Parasitology, School of Veterinary Medicine, Philadelphia, Pennsylvania 19104
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D. M. H. Kadivar
D. M. H. Kadivar
Laboratory of Parasitology, School of Veterinary Medicine, Philadelphia, Pennsylvania 19104
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E. J. L. Soulsby
E. J. L. Soulsby
Laboratory of Parasitology, School of Veterinary Medicine, Philadelphia, Pennsylvania 19104
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Delayed hypersensitivity phenomena in cutaneous leishmaniasis of the guinea pig, caused by Leishmania enriettii, were investigated with an antigen prepared from promastigotes grown in culture. Cutaneous delayed-type hypersensitivity was shown to persist for several months after resolution of lesions. Two in vitro correlates of delayed hypersensitivity, blastoid transformation of peripheral blood lymphocytes and the inhibition of migration of peritoneal macrophages, were also positive. Macrophage inhibition persisted several months after resolution. These results suggest that immunity to this form of leishmaniasis is cell-mediated.
Author Notes
Present address: School of Medicine, Pahlavi University, Shiraz, Iran.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 383 | 162 | 7 |
| Full Text Views | 11 | 1 | 0 |
| PDF Downloads | 7 | 2 | 0 |