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Plasmodium Vivax Infections in Aotus Trivirgatus
James A. Porter Jr.
James A. Porter Jr.
Miami Veterans Administration Hospital (151), 1201 Northwest 16th Street, Miami, Florida 33125
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Parasitemia in night monkeys (Aotus trivirgatus) produced by infection with the Achiote and Santa Rosa strains of Plasmodium vivax was studied in normal and splenectomized animals, and in animals with and without spleens treated with azathioprine (Imuran®). Infections were produced by inoculation of blood from man in 17 (65.4%) of 26 animals, from other night monkeys in 213 (90.3%) of 236 animals, and from a Panamanian marmoset (Saguinus geoffroyi) in 1 of 2 animals. Infection was obtained in 111 (91.7%) of 121 normal monkeys, in 6 (85.7%) of 7 given azathioprine, in 15 (68.2%) of 22 splenectomized animals, and in 81 (94.2%) of 86 splenectomized animals given azathioprine. The Achiote strain has been through 56 passages and the Santa Rosa strain through 38 passages. During later passages of these strains, patent parasitemia lasted for 3 to 4 weeks, and average maximum parasitemia ranged from 15,000 to 40,000 per mm3. Parasitemia was consistently higher in night monkeys, with and without spleens, treated with azathioprine, and in splenectomized animals not treated with azathioprine, than in normal animals.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 326 | 121 | 15 |
| Full Text Views | 8 | 2 | 0 |
| PDF Downloads | 6 | 6 | 0 |