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In an epidemic of viral hepatitis caused by polluted water, 97 of 981 persons examined showed evidence of hepatitis. None of these 97 persons gave evidence of infection with Australia/SH antigen. In 26 persons randomly selected from those with hepatitis, immunoglobulin (IgG and IgM) levels were significantly elevated. We concluded that the causative agent of this short-incubation period hepatitis, which resembled infectious hepatitis, was antigenically different from Australia/SH antigen.