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The larvicidal effect of Dichlorvos® was evaluated against the free-living stages of Ancylostoma caninum in Harada-Mori and charcoal cultures containing Dichlorvos resin pellets. The effect of single pellets on the larvae in water was tested also by transferring pellets periodically, and by exposing larvae for one period and allowing various periods for recovery. Fecal samples from treated dogs were collected until all pellets had been passed and were cultured in charcoal. The drug killed the larvae under all conditions tested. There appeared to be no interference with the development of eggs or the hatching of larvae. However, a few larvae survived to the infective stage (L3). Larvae at all stages of development were equally susceptible to the drug. Posttreatment fecal cultures produced few or no infective larvae. The toxic effects of Dichlorvos appear to be irreversible. The larvicidal properties of the drug may add significance to the benefits of treatment with Dichlorvos in the control of hookworm infection.
Present address: University of Georgia, School of Veterinary Medicine, Southeastern Cooperative Wildlife Disease Study, Department of Parasitology, Athens, Georgia 30601.