By Everard L. Napier, M.R.C.S., L.R.C.P. (Lond.). In charge Kala-azar research, Calcutta School of Tropical Medicine. Second edition. 185 pages of text with 15 charts in the text, 18 plates, and an appendix of references to literature, author index and subject index. Oxford University Press. London, Bombay, Calcutta, Madras, 1927
Yomesan—N-(2′-chlor-4′-nitrophenyl)-5 chlorsalicylamid—was ineffective in 10 children with Hymenolepis nana infections who were treated with a single dose of 100 mg per kg of body weight. On the other hand, at least 90% of 62 children who received 40 to 80 mg per kg per day for 5 days were cured as evidenced by negative stool examinations performed weekly or biweekly for 10 to 12 weeks after treatment. Nine untreated children used as controls and similarly examined remained positive throughout the observation period. No objective signs of intolerance or toxicity were noted. In view of the world-wide reports of the efficacy and safety of Yomesan (niclosamide) in the treatment of Taenia infections and its extensive use in many parts of the world, we suggest that this drug be made available in the United States.