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Fifteen milligrams of primaquine base administered daily for 14 days, in conjunction with standard chloroquine therapy (1.5 gm. base or 2.5 gm. chloroquine diphosphate in 3 days), constitutes the treatment of choice for the radical cure of Plasmodium vivax of Korean origin during late clinical activity. This therapeutic schedule may be safely continued on an ambulatory basis with only minimum medical supervision after acute symptoms have subsided.
Clinically significant toxicity was not observed with either primaquine or pamaquine, although in the dosage employed pamaquine is potentially toxic in a small percentage of Negroes.
Department of Medicine, University of Chicago.
First Lieut., Captain, Captain, Lt. Colonel, respectively, MC, U.S.A.
Laboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health.
Department of Medicine, University of Pennsylvania.