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Korean vivax malaria exhibits a bimodal pattern of clinical activity and a period of long-term latency similar to other strains of Plasmodium vivax originating in temperate climates. It was possible to define many aspects of the natural history of this strain with a fair degree of accuracy in large numbers of men infected in the field. The pattern of clinical activity of Korean vivax malaria is similar in all major respects to the pattern of the St. Elizabeth strain (Table 3). In the absence of reinfection during a second transmission season, Korean vivax malaria acquired in the field terminates spontaneously within two years. Negroes appear to be less susceptible to infection with this strain of vivax malaria than Caucasians. A follow-up period of four months is adequate to determine the effect of a therapeutic agent on the relapse rate, when the majority of attacks are late attacks.
First Lieut., Captain, Captain, Lt. Colonel, respectively, MC, U.S.A.
Department of Medicine, University of Pennsylvania.
Laboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health.
Department of Medicine, University of Chicago.