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Survey of Antimalarial Agents

Chemotherapy of Plasmodium gallinaceum infections; toxicity; correlation of structure and action. Public Health Monograph No. 9. By G. Robert Coatney, W. Clark Cooper, Nathan B. Eddy and Joseph Greenberg. 323 pp. Washington, D. C., Federal Security Agency, Public Health Service, P.H.S. Publication 193, Superintendent of Documents. Price $1.25

L. W. Hackett
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Since 1941, nearly 4,000 substances have been screened for antimalarial activity against Plasmodium gallinaceum. Some have been studied clinically and reported in a long series of papers in various journals. The main purpose of these studies was to “arrange the compounds as consistently as possible according to chemical relationships and to analyze the accumulated data for the light that may be thrown on the relation between antimalarial activity and chemical structure.” The tabulated data present the degree of toleration of the drugs by chicks, their antimalarial activity and the therapeutic index of each, that is, the maximum tolerated dose divided by the minimum effective therapeutic dose.

This imposing piece of work deals with fourteen groups of compounds arranged in 129 tables. A general summary reviews all of the compounds which showed significant antimalarial action. Seventy-seven compounds had a therapeutic dose approximately equivalent to that of quinine, three-quarters of which were amino-quinolines.