Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
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0002-9637
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A Further Study of the Toxicity of Pyrimethamine (Daraprim) in Man

A. V. MyattLaboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health, Bethesda 14, Maryland

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G. Robert CoatneyLaboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health, Bethesda 14, Maryland

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Thomas HernandezLaboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health, Bethesda 14, Maryland

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Herbert W. BurtonLaboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health, Bethesda 14, Maryland

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DOI:
https://doi.org/10.4269/ajtmh.1953.2.1000
Volume/Issue:
Volume 2: Issue 6
Page(s):
1000–1001
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Summary and Conclusions

Reported therapeutic tests show that pyrimethamine is an effective suppressant for malaria in dosage of 25 mg. single dose weekly. Our studies reported here and previously (Coatney et al., 1953) indicate that this dosage may be given safely to white or colored races without untoward reactions, barring possible cases of idiosyncrasy.
Published Online:
Nov 1953
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