Filariasis in American Samoa

III. Studies on Chemotherapy Against the Nonperiodic Form of Wuchereria Bancrofti

G. F. Otto School of Hygiene and Public Health of The Johns Hopkins University and the U. S. Naval Medical Research Institute

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L. A. Jachowski Jr. School of Hygiene and Public Health of The Johns Hopkins University and the U. S. Naval Medical Research Institute

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J. D. Wharton School of Hygiene and Public Health of The Johns Hopkins University and the U. S. Naval Medical Research Institute

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DOI:
https://doi.org/10.4269/ajtmh.1953.2.495
Volume/Issue:
Volume 2: Issue 3
Page(s):
495–516
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Summary

Diethylcarbamazine is rapidly microfilaricidal but there has been no demonstration that the adult worms are killed. Its possible place as an adjuvant public health measure in the control of filariasis is yet to be demonstrated. Thiacetarsamide is very slowly microfilaricidal but the results are more permanent and that, together with collateral laboratory evidence, suggests that the adult worms are killed. This drug must however, be, given intravenously, apparently daily for not less than 15 days, and thus has limited value as a community-wide public health measure.

Author Notes

Published Online:
May 1953
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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