The Effect of a Cyanine Dye on Infections with Hookworm and Trichuris in Man

Enrique Pérez-SantiagoDepartments of Clinical Medicine and Medical Zoology, School of Tropical Medicine, San Juan, Puerto Rico

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José Oliver-GonzálezDepartments of Clinical Medicine and Medical Zoology, School of Tropical Medicine, San Juan, Puerto Rico

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Carlos J. ThilletDepartments of Clinical Medicine and Medical Zoology, School of Tropical Medicine, San Juan, Puerto Rico

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Summary

The administration of compound #715 to patients infected with hookworm caused expulsion of some of the adult worms. As the doses and frequency of administration increased, the number of worms expelled also increased, but it was never as effective nor as well tolerated as tetrachlorethylene. Adult Trichuris trichiura also were passed during administration of #715.

Frequent complaints during drug administration were nausea, vomiting, and epigastric pain. These reactions, however, did not warrant discontinuation of treatment.

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