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The Nature of Melanoma

by Vincent J. McGovern, director of the Fairfax Institute of Pathology, Royal Prince Alfred Hospital, Lecturer in Pathology, University of Sydney, Australia; and Malcolm M. Lane Brown, Research fellow in the Department of Surgery, University of Sydney. xi + 184 pages, illustrated. Charles C Thomas, Springfield, Illinois. 1969. $12.75

Diane W. CrockerAssistant Professor of Pathology Harvard Medical School and Peter Bent Brigham Hospital 721 Huntington Avenue, Boston, Massachusetts 02115

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This book represents a remarkably compact, factual, and well-organized coverage of melanoma. The entire subject is presented in 184 pages of easily readable print and accompanied by many good-quality gross and microscopical illustrations. The first four chapters are devoted to melanogenesis, including detailed presentations of the chemistry thereof and the regulation of melanogenesis in mammalian tissues, including human. The effect of metals, irradiation, ultraviolet light, and other factors on melanogenesis are also covered. A separate chapter is devoted to abnormalities of pigmentation in man, with excellent references to current electron microscopical observations on pre-melanosomes and melanocytes. The subsequent eight chapters pertain primarily to various forms of nevi and melanoma in man. These chapters have a concise presentation of the classification of both benign and malignant melanotic lesions with clear-cut gross and microscopical descriptions and important clinical criteria. Although the authors have abbreviated Dr. Wallace Clark's classification of lentigo, it is included.