Long-Term Persistence of Modoc Virus in Hamster-Kidney Cells

In vivo and in vitro Demonstration

Harald Norlin JohnsonViral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley, California 94704

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Modoc virus, a member of group B of the arthropod-borne viruses, produced an infection in a hamster with excretion of the virus in the urine for a period of 5 months. The presence of the virus in the kidney in a state of latency was demonstrated by cell culture of kidney tissue at 14 months after inoculation with the virus. The blood serum contained a high level of antibody against the virus. and direct inoculation of the kidney tissue into animals did not reveal active virus.