Cache Valley Virus in the Del Mar Va Peninsula

III. Serologic Evidence for Natural Infection of Dairy Cattle

Thomas M. YuillDivision of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Live Stock Sanitary Service, Maryland State Board of Agriculture, Department of Veterinary Science, University of Maryland, Washington, D. C. 20012

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William S. Gochenour Jr.Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Live Stock Sanitary Service, Maryland State Board of Agriculture, Department of Veterinary Science, University of Maryland, Washington, D. C. 20012

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Francis R. LucasDivision of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Live Stock Sanitary Service, Maryland State Board of Agriculture, Department of Veterinary Science, University of Maryland, Washington, D. C. 20012

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Michael J. Collins Jr.Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Live Stock Sanitary Service, Maryland State Board of Agriculture, Department of Veterinary Science, University of Maryland, Washington, D. C. 20012

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Edward L. BuescherDivision of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Live Stock Sanitary Service, Maryland State Board of Agriculture, Department of Veterinary Science, University of Maryland, Washington, D. C. 20012

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Preliminary observations indicating that cattle resident in coastal Maryland and Virginia are natural hosts for Cache Valley virus were confirmed by extended serologic surveys. That virus-neutralizing substances in cattle were indeed antibody was established by demonstration that serum antiviral activity resided in bovine immunoglobulins. Agespecific antibody prevalence was highest in cattle reared in coastal areas, and declined in piedmont or mountainous regions. In 1964 and 1965 about 50% of susceptible cattle of nine dairy herds in the endemic area became infected.

Author Notes

Present address: Department of Veterinary Science, University of Wisconsin, Madison, Wisconsin 53706.

Present address: Microbiological Associates, Bethesda, Maryland 20014.

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