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A new synthetic substance, phenylene-diisothiocyanate, was tried in 80 patients with hookworm. In the first phase of the investigation, 40 patients were treated, with different dose schedules and complete laboratory studies, to assess the best dose and the safety of the drug. In the second phase of the study a dose of 100 mg every 12 hours, times three, was found to be best. Careful parasitologic studies were performed, with the Stoll and the Beaver egg-counting methods. An average of 14 to 21 egg counts were performed for each patient. The patients that received the previously mentioned dose had reductions in egg counts from 92 to 96%, results that can be considered excellent and superior to those obtained with other drugs, according to our experience. Fifty-seven percent of the patients complained of side-effects, mainly gastrointestinal, most of which were of mild or medium intensity. No toxic effects were revealed by the blood and urine tests performed.