Effect of the Administration of the Antischistosomal Drug Niridazole on Muscle Glycogen Levels of Monkeys

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  • Department of Pathobiology, School of Hygiene and Public Health, Department of Pharmacology and Experimental Therapeutics, School of Medicine, The Johns Hopkins University, Department of Medical Zoology, Walter Reed Army Institute of Research, Baltimore, Maryland 21205

Niridazole was administered to 57 rhesus monkeys at a dosage schedule approximating the minimally curative dose for schistosomiasis mansoni of this species. This resulted in a marked depletion of the muscle glycogen stores, which was attributed in part to a reduced food intake due to anorexia produced by the drug and in part to an inhibition of phosphorylase phosphatase, activity bringing about an accumulation of active glycogen phosphorylase. Restoration of muscle glycogen levels to control values was observed about 8 days after discontinuation of drug administration.