Temporal Relation between a Serum Electroadsorbing Fraction and the Course of Acute Plasmodium Berghei Malaria in Rats

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  • Department of Zoology, University of Illinois, The Rockefeller University, Urbana, Illinois
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The temporal relations of a serum electroadsorbing factor (S. E. A. F.) that, quantitatively electroadsorbed from the serum of normal and Plasmodium berghei-infected rats, were determined by a modification of the immunoelectroadsorption (I. E. A.) technique. The S. E. A. F. electroadsorbed independently of the presence of a specific P. berghei antigen. It tended to increase slowly with time in normal rats. It was found to increase markedly and abruptly after the 5th day of P. berghei infection, and its pattern of increase appeared to accompany the typical pattern of acute P. berghei anemia and parasitemia. The S. E. A. F. remained elevated for varying periods after the resolution of infection. Its role in normal and pathophysiologic processes is presently unknown, as is its origin or identity. Its appearance interferes with the I. E. A. test, and reference is made to studies describing a resolution to this difficulty.