Dengue Type 3 Virus Isolated from an Antiguan Patient during the 1963–64 Caribbean Epidemic

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  • University of the West Indies, Trinidad Regional Virus Laboratory, Yale Arbovirus Research Unit, Yale University School of Medicine, P. O. Box 164, Port-of-Spain, Trinidad

A strain of dengue type 3 virus was isolated from the blood of an Antiguan patient in cell cultures of African green-monkey kidney during studies on a dengue outbreak that occurred in the Caribbean region in 1963 and 1964. The virus was adapted to mice by blind intracerebral passage. Illness appeared in mice at the 11th mouse-brain passage. Four other agents, presumed to be dengue type 3 strains, were isolated from Antiguan patients. Serologic studies on paired serum samples from patients of five Caribbean territories showed that the outbreak was due to a group B arbovirus.

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