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Data from three nonimmune North Americans who acquired malaria in a highly endemic area of Colombia, and data from a field trial with infected natives in the same area, indicated the presence of chloroquine-resistant Plasmodium falciparum in the area. This is the first report of chloroquine-resistant malaria from the Pacific coast of the Western Hemisphere.
Evidence for chloroquine-resistance in the natives was found only in the children. It is concluded that tests for suspected chloroquineresistance in P. falciparum in native populations of endemic areas are best done in the younger age-groups.
Atlantic-Pacific Interoceanic Canal Commission, U. S. Army, Canal Zone.