Lipid Synthesis from Glucose Carbon by Plasmodium Berghei, in Vitro

Richard J. CenedellaDepartment of Pharmacology, West Virginia University Medical Center, Morgantown, West Virginia 26506

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Intraerythrocytic Plasmodium berghei readily incorporated labeled glucose carbon into lipids in vitro. Essentially all of the incorporation represented phospholipid synthesis, mainly cephalins. The glucose carbon entering phospholipids did so primarily by way of α-glycerol phosphate since less than 5% of the total incorporation represented fatty-acid synthesis. The results suggest that the parasite exhibits at least a partial dependence upon its environment for a source of fatty acid.