Methods in Virology

Edited by Karl Maramorosch and Hilary Koprowski. Academic Press, New York and London, 1967, Vol. II, 682 pp., $28.00

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  • Departments of Medicine & Bacteriology University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514

This volume marks the direction of progress in the field of virology. It deals with the purification and separation of viruses and their components as well as their characterization by the physical means common to those used throughout the field of molecular biology. Roy Markham in the first chapter, setting about to dispel the mystery surrounding the use of the analytic ultracentrifuge, maintains that the instrument is easier to learn to use than an automobile, and less dangerous. His chapter is a model of clarity and contains instances of friendly solicitude; for example: “A strip of carpet in front of the machine is a great convenience for kneeling when loading the rotor.”

H. M. Mazzone's chapter on equilibrium ultracentrifugation is more formal. There is a somewhat excessive examination of the theory and calculations underlying the method at the expense of practical methodology, especially as applied to viruses.