The Influence of Chicken Serum Proteins on the Infection of Aedes Aegypti with Plasmodium Gallinaceum

Reza Behin Laboratories of Medical Entomology, Department of Pathobiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205

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Aedes aegypti females were fed through a membrane on Plasmodium gallinaceum-infected red blood cells suspended in whole chicken serum, serum fractions, or saline solution. The relative effect of the ingested host proteins on the development of the parasites in the mosquitoes was determined by counting the oöcysts on the guts of the mosquitoes after a 6-day incubation period. The relative effectiveness of the test materials was as follows. A protein containing both globulin and albumin fractions was about equal to whole serum. Chick serum albumin, fraction V, was inferior to whole serum, but superior to saline solution. A protein fraction containing the globulin but not albumin was comparable to saline solution.

The results of these experiments suggest that albumin may be the most important single component of vertebrate blood serum that supports growth of the oöcysts of malaria parasites in susceptible mosquitoes. However, for maximum growth the total protein of the serum must be present.

Author Notes

Present address: Gondi-Shapour University, School of Medicine, Ahwaz, Iran.