Fluorescent Antibody Studies in Human Malaria

V. Response of Sera from Nigerians to Five Plasmodium Antigens

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  • Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Chamblee, Georgia

Summary

A total of 498 sera from Nigerians was tested for the presence of antibody to malaria, using five Plasmodium antigens and the indirect fluorescent antibody technique.

The average FA response was highest to P. falciparum, followed by P. fieldi, P. brasilianum, P. ovale, and P. vivax. The average FA endpoint increased with the age of the individual with all the antigens. The P. brasilianum antigen, usually indicative of P. malariae response, was low in its response to sera of children, but was equal to the P. falciparum response with sera from individuals 13 years of age and older. There appeared to be a higher average response in the males than in the females.

Author Notes

Present address: Laboratory of Chemical Biology, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014.

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