edited by W. H. Taliaferro, Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, and J. H. Humphrey, National Institute of Medical Research, London, England. Vol. 1, x + 423 pages, illustrated. New York, London, Academic Press. 1961. $12.00
V. Evaluation of Cross-Immunity against Type 1 Dengue Fever in Human Subjects Convalescent from Subclinical Natural Japanese Encephalitis Virus Infection and Vaccinated with 17D Strain Yellow Fever Vaccine
The concentration of Toxocara or Ascaris antigens that induced nonspecific reactions was determined. Lesion sizes of specific reactions varied directly with the amount of antibody used for sensitization and the amount of antigen used for challenge. High concentrations of antibody influenced lesion size of adjacent sites, apparently by diffusion of excess antibody into such sites. With the use of the modified PCA procedure, antibody could be demonstrated by the 2nd week in sera from Toxocara-infected rabbits and guinea pigs.