Fluorescent-Antibody Studies on Simian Malaria

II. Development of Antibodies to Plasmodium Cynomolgi

William E. CollinsNational Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, Section on Primate Malaria, P. O. Box 190, Chamblee, Georgia 30005

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Jimmie C. SkinnerNational Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, Section on Primate Malaria, P. O. Box 190, Chamblee, Georgia 30005

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Peter G. ContacosNational Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, Section on Primate Malaria, P. O. Box 190, Chamblee, Georgia 30005

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Elizabeth G. GuinnNational Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, Section on Primate Malaria, P. O. Box 190, Chamblee, Georgia 30005

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Summary

The fluorescent-antibody responses were determined during the course of infection in nine Macaca mulatta monkeys infected with Plasmodium cynomolgi.

FA response increased initially in both sporozoite and blood-induced infections, reaching an initial peak titer that was often as high as, or higher than, that found after extended periods of parasitemia. There was a rapid decline in FA response in one case following the elimination of the infection by chemotherapy after a brief parasitemia. Similarly, splenectomy of two animals during the infection resulted in a rapid, but temporary, decline in FA response.

The FA response to the P. fieldi antigen was similar to the homologous response, suggesting the usefulness of this antigen as a substitute for homologous antigens in such studies.

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